Board the "Powell/Hyde" cable car at Powell & Market Street (there are 2 Cable Cars...the other is the Powell/Mason... don't take that one).  Try to grab a spot on the outside right rail if you can,  hold on tight and wait for stops to take pictures!  About halfway is the 'Crooked Street' (Lombard Street) for some quick pics.  Continue to the end of the line and you'll be at Fisherman's Wharf.